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KMID : 0359319990390040724
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Korean Journal of Veterinary Research
1999 Volume.39 No. 4 p.724 ~ p.729
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Korean Variant dogs have red blood cells with high amino acid accumulation
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Fujise, Hiroshi
Lim, Yoon Kyu/Lee, Kyoung Kap/Kim, Seong Hee/Kim, Sung Sun/Kim, Gon Hyung/Kim, Ji Hyun
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Abstract
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Amino acids, Na, K and glutathione (GSH) in red blood cells (RBCs) and hematological indices were examined in Korean dogs. A total of seven dogs possessing RBCs with high K and high glutathione (GSH)(HK/HG) were found in 42 Korean dogs : three from Cheju dog, two from Jindo dog and two from Korean mongrel. The RBCs in Korean HK/HG dog contained abnormally high aspartate (Asp), Glu and glutamine (Gln) the same as in HK/HG RBCs from Japanese Shiba dog. Two dogs possessing RBCs with HK and low GSH (HK/LG) were found in Cheju dog, and they accumulated Asp and Gln. Thus, not only the existence of HK dog was confirmed in Korean dogs, but HK/LG dog was also found. The Asp concentration in RBCs from seven of 33 LK dogs was more than 1000μmol/lc, the same as in variant LK RBCs with defective Glu/Asp transport (LK/GAT), while it was less than 800μmol/lc in normal LK RBCs. Thus, there were variant dogs having RBCs with abnormally high amino acids accumulation among HK and LK Korean dogs.
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KEYWORD
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